David A Brown Selected Research

arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamide

1/2020	The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats.
1/2016	Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia.
11/2015	Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart.
1/2014	Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia.
4/2013	Rationale and design of the EMBRACE STEMI study: a phase 2a, randomized, double-blind, placebo-controlled trial to evaluate the safety, tolerability and efficacy of intravenous Bendavia on reperfusion injury in patients treated with standard therapy including primary percutaneous coronary intervention and stenting for ST-segment elevation myocardial infarction.
6/2012	Reduction of ischemia/reperfusion injury with bendavia, a mitochondria-targeting cytoprotective Peptide.
5/2012	Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury.

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David A Brown Research Topics

Disease

28	Neoplasms (Cancer) 01/2020 - 03/2003
19	Ischemia 01/2022 - 02/2003
14	Reperfusion Injury 01/2022 - 04/2005
9	Infarction (Infarctions) 10/2019 - 12/2003
8	Myocardial Infarction 11/2017 - 04/2005
8	Prostatic Neoplasms (Prostate Cancer) 11/2009 - 08/2003
7	Anorexia 12/2019 - 11/2007
6	Hypoxia (Hypoxemia) 01/2020 - 07/2007
6	Cachexia 12/2019 - 10/2011
5	Wounds and Injuries (Trauma) 01/2022 - 05/2016
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 11/2010
5	Inflammation (Inflammations) 01/2019 - 10/2011
5	Heart Failure 12/2018 - 02/2006
5	Stroke (Strokes) 10/2013 - 06/2002
4	Obesity 01/2018 - 01/2012
4	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/2016 - 11/2011
4	Pain (Aches) 12/2011 - 08/2003
3	Necrosis 01/2021 - 07/2013
3	Multiple Sclerosis 01/2021 - 12/2012
3	Demyelinating Diseases (Demyelinating Disease) 01/2020 - 01/2019
3	Weight Loss (Weight Reduction) 12/2019 - 11/2007
3	Body Weight (Weight, Body) 12/2019 - 01/2012
3	Muscular Diseases (Myopathy) 01/2016 - 01/2015
3	Neoplasm Metastasis (Metastasis) 01/2012 - 03/2007
3	Cardiac Arrhythmias (Arrythmia) 12/2011 - 04/2010
3	Melanoma (Melanoma, Malignant) 02/2009 - 12/2003
3	Skin Neoplasms (Skin Cancer) 11/2005 - 09/2002
2	Immunoglobulin G4-Related Disease 08/2022 - 01/2022
2	COVID-19 02/2022 - 01/2021
2	Ovarian Neoplasms (Ovarian Cancer) 01/2020 - 03/2003
2	Neuroinflammatory Diseases 01/2019 - 03/2014
2	Autoimmune Diseases (Autoimmune Disease) 01/2019 - 01/2017
2	Breast Neoplasms (Breast Cancer) 07/2014 - 09/2002
2	Atherosclerosis 11/2012 - 03/2007
2	Colorectal Neoplasms (Colorectal Cancer) 02/2012 - 03/2003
2	Ventricular Fibrillation 12/2011 - 04/2010
2	Infections 03/2010 - 06/2002
2	Aneurysm (Aneurysms) 09/2009 - 05/2004
2	Hypertrophy 07/2007 - 02/2006
2	Pancreatic Neoplasms (Pancreatic Cancer) 01/2006 - 04/2004
2	Adenocarcinoma 01/2006 - 04/2004
2	Xeroderma Pigmentosum (Kaposi's Disease) 04/2005 - 09/2002
2	Carcinoma (Carcinomatosis) 03/2005 - 03/2003
2	Hemiplegia (Spastic Hemiplegia) 02/2005 - 05/2004
1	Dermatomyositis (Dermatopolymyositis) 02/2022
1	Wound Infection (Wound Infections) 01/2022
1	Dengue (Dengue Fever) 12/2021

Drug/Important Bio-Agent (IBA)

17	CytokinesIBA 01/2020 - 03/2003
17	Growth Differentiation Factor 15IBA 12/2019 - 03/2003
13	Transforming Growth Factor beta (TGF-beta)IBA 01/2020 - 03/2003
12	Biomarkers (Surrogate Marker)IBA 01/2021 - 03/2003
12	Proteins (Proteins, Gene)FDA Link 01/2020 - 03/2003
8	Adenosine Triphosphate (ATP)IBA 01/2022 - 04/2005
8	Peptides (Polypeptides)IBA 01/2020 - 03/2003
7	arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamideIBA 01/2020 - 05/2012
6	Pharmaceutical PreparationsIBA 01/2020 - 11/2010
5	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 06/2012
5	Cardiolipins (Cardiolipin)IBA 01/2020 - 07/2014
5	Myelin-Oligodendrocyte GlycoproteinIBA 01/2020 - 11/2011
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2015 - 03/2003
3	AntibodiesIBA 01/2021 - 09/2002
3	Phospholipids (Phosphatides)FDA LinkGeneric 01/2020 - 11/2015
3	AutoantibodiesIBA 01/2020 - 01/2019
3	LipidsIBA 12/2019 - 12/2013
3	Monoclonal AntibodiesIBA 12/2019 - 10/2011
3	EnzymesIBA 10/2017 - 04/2013
3	KATP ChannelsIBA 04/2014 - 06/2006
3	Prostate-Specific Antigen (Semenogelase)IBA 11/2009 - 01/2006
2	Immunoglobulin G (IgG)IBA 08/2022 - 01/2022
2	RNA (Ribonucleic Acid)IBA 01/2021 - 04/2004
2	BradykininIBA 01/2020 - 05/2010
2	Small Interfering RNA (siRNA)IBA 12/2019 - 02/2009
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 01/2018 - 01/2015
2	Biological ProductsIBA 12/2017 - 12/2009
2	GoldIBA 04/2017 - 01/2017
2	CalciumIBA 03/2016 - 05/2012
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2013 - 12/2003
2	Opioid Analgesics (Opioids)IBA 09/2012 - 07/2011
2	Sulfhydryl Compounds (Thiols)IBA 05/2012 - 12/2011
2	DiamideIBA 12/2011 - 04/2010
2	Glutathione (Reduced Glutathione)IBA 12/2011 - 04/2010
2	PotassiumIBA 11/2010 - 06/2006
2	Messenger RNA (mRNA)IBA 12/2009 - 06/2003
2	Hormones (Hormone)IBA 10/2009 - 03/2003
2	ezogabine (retigabine)IBA 04/2009 - 08/2003
2	ElementsIBA 11/2007 - 07/2007
2	Carrier Proteins (Binding Protein)IBA 07/2007 - 03/2005
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2006 - 12/2003
1	BNT162 VaccineIBA 02/2022
1	SteroidsIBA 01/2022
1	Oxygen (Dioxygen)IBA 01/2022
1	Succinic Acid (Succinate)IBA 01/2022
1	anti-GFAP autoantibodiesIBA 12/2021

Therapy/Procedure

18	Therapeutics 01/2020 - 08/2003
3	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 05/2004 - 02/2003
2	Resistance Training 12/2011 - 12/2007
2	Physical Therapy Modalities (Physical Therapy Technique) 12/2011 - 02/2005
2	Prostatectomy (Retropubic Prostatectomy) 04/2006 - 03/2005
2	Cardiopulmonary Bypass (Heart-Lung Bypass) 05/2004 - 02/2003
1	Operative Time 01/2022